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KMID : 1007520150240020771
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Food Science and Biotechnology
2015 Volume.24 No. 2 p.771 ~ p.776
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Effects of Elevated Intracellular Cyclic di-GMP Levels on Biofilm Formation and Transcription Profiles of Vibrio vulnificus
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Park Jin-Hwan
Lim Jong-Gyu
Choi Sang-Ho
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Abstract
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Effects of elevated intracellular 3',5'-cyclic diguanylic acid (c-di-GMP) levels on biofilm formation and transcription profiles were evaluated to assess the functions of c-di-GMP in Vibrio vulnificus. Elevated c-di- GMP levels promoted biofilm formation and rugose colony development. Microarray analysis revealed that c-di-GMP influenced expression of genes belonging to different functional categories and more than 5% of the V. vulnificus genome. Among these, 10 genes potentially involved in biofilm formation were experimentally verified as subject to c-di-GMP regulation. c-di-GMP contributes to biofilm formation based on modulation of diverse cellular processes in V. vulnificus.
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KEYWORD
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3', 5'-cyclic diguanylic acid (c-di-GMP), Vibrio vulnificus, transcriptome analysis, biofilm, rugose colony
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